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These findings indicate that PlexinB1 and PlexinB2 have a role in the inactivation of RanGTP

GPX4 has been found at high levels in cancer cells and contributes to drug-resistance against lapatinib, palbociclib and other anti-cancer drugs

Inhibition of the Xc-system determines the decrease in GSH levels, which indirectly leads to the inactivation of GPX4 and the onset of ferroptosis ( 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)

Each sample was analyzed three times and the level of JA was calculated by referring to a standard curve